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Venous thromboembolism in patients with COVID-19 and correlation with D-dimers: a single-centre experience

Muhammad Ziaullah Khan1, Yousaf Jamal2, Benjamin Sutton2

  • 1Department of Respiratory Medicine, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom ziaullah.khan@nhs.net.

BMJ Open Respiratory Research
|November 17, 2020
PubMed

Insights

Venous thromboembolism (VTE) occurred in 11.2% of hospitalized COVID-19 patients. Elevated D-dimer levels significantly correlate with VTE risk, necessitating further evaluation in patients with levels above 2000 ng/mL.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Cardiology

Background:

  • COVID-19 is associated with an increased risk of venous thromboembolism (VTE).
  • Understanding the frequency and risk factors for VTE in hospitalized COVID-19 patients is crucial for effective management.
  • D-dimer levels are a potential biomarker for VTE risk.

Purpose of the Study:

  • To determine the incidence of VTE in hospitalized patients with COVID-19 pneumonia.
  • To investigate the correlation between D-dimer levels and VTE in this patient cohort.
  • To assess the role of thromboprophylaxis in preventing VTE.

Main Methods:

  • A cross-sectional descriptive study was conducted at Queen Elizabeth Hospital from April 20 to May 13, 2020.
  • 107 patients with PCR-confirmed COVID-19 pneumonia were included.
  • Data on demographics, D-dimer levels, VTE occurrence, and anticoagulation were collected and analyzed.

Main Results:

  • The frequency of VTE was 11.2% among hospitalized COVID-19 patients.
  • Mean D-dimer levels were significantly higher in patients with VTE and those admitted to the intensive care unit.
  • 100% of patients with D-dimer levels above 2000 ng/mL who underwent imaging had VTE.

Conclusions:

  • VTE is a significant complication in hospitalized COVID-19 patients, even with anticoagulation.
  • Elevated D-dimer levels strongly correlate with VTE risk.
  • Further investigation for VTE is recommended for COVID-19 patients with D-dimer levels exceeding 2000 ng/mL.
Abstract

Keywords:
pulmonary embolismrespiratory Infectionviral infection

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