Oestrogen and the differentiation of granulated metrial gland cells in chimeric mice

The role of oestrogen in the recruitment of GMG cell precursors to the uterus has been investigated in radiation-induced chimeric mice reconstituted with rat bone marrow and maintained on a hormone regime simulating pseudopregnancy. The presence of rat GMG cells in the deciduomata in mice irradiated after oestrogen priming suggests that oestrogen priming is not an essential factor in recruiting GMG cell precursors. However, the results have led to the suggestion that in the normal, cycling mouse oestrogen may have a role in attracting GMG cell precursors to the uterus and preparing them for differentiation.