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Updated: Nov 30, 2025

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Cardiovascular Risk Reduction With Icosapent Ethyl: A Systematic Literature Review
Mala Thakur1, Pritpal S Sangha2, Areesha Satti3
1Internal Medicine, Xavier University School of Medicine, Oranjestad, ABW.
Insights
Elevated triglyceride levels increase cardiovascular disease risk. Icosapent ethyl, a statin therapy, effectively reduces heart complications and ischemic events.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Cardiovascular disease is a leading cause of death in the US.
- Elevated triglyceride levels are a significant risk factor for ischemic events.
- Predisposing conditions include genetic factors, cholesterol, lipoproteins, and triglycerides.
Purpose of the Study:
- To review the efficacy of icosapent ethyl in reducing cardiovascular risks.
- To analyze the role of statin therapy in managing heart complications associated with high triglycerides.
Main Methods:
- Literature review of existing research and analyses.
- Examination of studies on statin therapy and its impact on cardiovascular health.
Main Results:
- Icosapent ethyl, as part of statin therapy, can reduce heart ailments.
- Evidence suggests a decrease in cardiovascular risks with icosapent ethyl use.
Conclusions:
- Icosapent ethyl demonstrates potential in mitigating cardiovascular risks.
- Managing triglyceride levels is crucial for preventing ischemic events and heart disease.
Abstract:
Cardiovascular disease is the leading cause of death in the United States of America due to elevated triglyceride levels. High triglyceride levels lead to higher risks of ischemic events. There are multiple pieces of research and analyses on statin therapy and its ability to reduce the prevalence of heart complications. Heart ailments can reduce through the use of icosapent ethyl in the form of statin therapy. This literature review will explain the reduction of cardiovascular risks with icosapent ethyl. Though some genetic conditions can cause some of these ailments, the rest of the predisposing conditions revolve around cholesterol, lipoproteins, and triglycerides.
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