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Targeted Cancer Therapies

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Related Experiment Video

Updated: Nov 30, 2025

Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

Published on: March 3, 2023

Colorectal liver metastases: Current management and future perspectives.

Jack Martin¹, Angelica Petrillo², Elizabeth C Smyth³

¹Department of Surgery, Addenbrookes Hospital, NIHR Comprehensive Biomedical Research and Academic Health Sciences Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom.

World Journal of Clinical Oncology

|November 17, 2020

Summary

Maximizing surgical resection of colorectal liver metastases (CRLM) is key for patient survival. Advanced multidisciplinary approaches and novel therapies improve outcomes for both resectable and unresectable CRLM.

Keywords:

Cancer Colorectal Liver Management Metastases Review

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Area of Science:

Hepatobiliary Surgery
Surgical Oncology
Gastroenterology

Background:

Colorectal cancer frequently metastasizes to the liver, affecting at least 25% of patients.
Management of colorectal liver metastases (CRLM) requires a multidisciplinary team approach.
Optimizing patient management relies on integrated clinical, radiological, and biomarker data.

Purpose of the Study:

To review current strategies for maximizing CRLM resection.
To discuss treatment options for unresectable CRLM.
To highlight evolving areas in CRLM management.

Main Methods:

Multidisciplinary team assessment.
Advanced imaging and biomarker analysis.
Surgical resection, chemotherapy, ablation, and radiotherapy.

Main Results:

Liver resection, when maximized, offers the best chance for long-term survival and cure.
Downsizing chemotherapy, PVE, ALPPS, and resection-ablation combinations enhance resectability.
For unresectable cases, systemic therapy, intra-arterial treatments, and radiotherapy improve survival and potential operability.

Conclusions:

Maximizing CRLM resection remains a primary objective, utilizing diverse techniques.
A range of treatments exists for unresectable CRLM, aiming to improve survival and convert to resectable disease.
Future directions include biomarker characterization, novel systemic agents, and potential re-emergence of liver transplantation.