Prothrombotic hemostasis disturbances in patients with severe COVID-19: Individual daily data

Area of Science:

• Hematology
• Critical Care Medicine
• Infectious Diseases

Background:

• Severe COVID-19 is associated with significant hemostatic disturbances.
• Understanding the temporal dynamics of these disturbances is crucial for managing thrombotic complications.

Purpose of the Study:

• To document longitudinal changes in a comprehensive panel of hemostasis markers in severe COVID-19 patients.
• To correlate these changes with clinical outcomes, including thrombotic and hemorrhagic events.

Main Methods:

• Prospective observational cohort study of 21 severe COVID-19 patients admitted to the ICU.
• Daily collection of plasma samples for analysis of coagulation factors, inhibitors, and global tests (thrombin generation, global fibrinolytic capacity).
• Collection of demographic, clinical, and complication data from electronic medical records.

Main Results:

• Detailed temporal profiles of C-reactive protein (CRP), platelet count, prothrombin time, fibrinogen, clotting factors II, V, VIII, D-dimers, antithrombin, protein C, protein S, tissue factor pathway inhibitor, PAI-1, von Willebrand factor, and ADAMTS-13 were established.
• Dynamic changes in thrombin generation and global fibrinolytic capacity were observed throughout the ICU stay.
• These hemostatic alterations were systematically recorded alongside patient clinical data and complications.

Conclusions:

• The study provides a detailed dataset on the evolving hemostatic profile in severe COVID-19 patients.
• This data is essential for further research into the pathophysiology of COVID-19-associated coagulopathy and for developing targeted therapies.
• The findings highlight the complex and dynamic nature of coagulation and fibrinolysis in critically ill COVID-19 patients.