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Related Experiment Video

Updated: Nov 30, 2025

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
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Nanostructure of DiR-Loaded Solid Lipid Nanoparticles with Potential Bioimaging Functions.

Lei Shu1, Fangqin Fu2, Zhengwei Huang3

  • 1Guangzhou Novaken Pharmaceutical Co., Ltd., Guangzhou, 510006, People's Republic of China.

AAPS Pharmscitech
|November 17, 2020
PubMed
Summary

This study introduces DiR-loaded solid lipid nanoparticles (DiR-SLNS) as biocompatible bioimaging agents. These safe, stable nanoparticles offer promising applications in nanotheranostics and advanced bioimaging.

Keywords:
DiRbioimagingnanostructuresolid lipid nanoparticle

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Area of Science:

  • Nanomedicine
  • Biomaterials
  • Bioimaging

Background:

  • Fluorescence dye-loaded nanoparticles are crucial for nanotheranostics but often use synthetic, potentially toxic materials.
  • Developing biocompatible alternatives is essential for safer bioimaging applications.

Purpose of the Study:

  • To investigate the potential of near-infrared probe DiR-containing solid lipid nanoparticle suspensions (DiR-SLNS) as biocompatible bioimaging agents.
  • To characterize the nanostructure, stability, and fluorescence properties of DiR-SLNS for nanotheranostics.

Main Methods:

  • Dissipative particle dynamics (DPD) simulations for nanostructure and dye distribution.
  • Dynamic laser scattering (DLS) and nanoparticle tracking analysis (NTA) for physicochemical stability.
  • Fluorescence spectroscopy to evaluate spectral properties and intensity-concentration correlation.

Main Results:

  • DiR-SLNS exhibited a "core-shell" nanostructure with DiR primarily in the cetyl palmitate core.
  • The nanoparticles demonstrated excellent physicochemical stability, retaining ~90% fluorescence intensity over 10 days.
  • A validated linear regression model established a reliable correlation between fluorescence intensity and concentration.

Conclusions:

  • DiR-SLNS represent a promising, biocompatible nano-scale candidate for bioimaging.
  • The high safety and fluorescence stability of DiR-SLNS are advantageous for nanotheranostics.
  • This lipid-based nanoparticle system offers a safer alternative to synthetic materials in bioimaging.