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Cross-reactivity

Cross-reactivity

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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Updated: Jul 2, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Experimental autoimmune prostatitis: different antigens induction and antigen-specific therapy.

Yuqian Liu¹, Junaid Wazir¹, Meng Tang¹

¹Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu, People's Republic of China.

International Urology and Nephrology

|November 17, 2020

Summary

Experimental autoimmune prostatitis (EAP) models are crucial for studying chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The T2 or p25 models show promise for both pathogenesis research and antigen-specific therapy development.

Keywords:

Animal model Autoantigens Chronic prostatitis/chronic pelvic pain syndrome Experimental autoimmune prostatitis Histopathology

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Last Updated: Jul 2, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

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Area of Science:

Urology
Immunology
Animal Models

Background:

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) presents diagnostic and therapeutic challenges due to uncertain etiology.
Autoimmunity is implicated in CP/CPPS pathogenesis, making experimental autoimmune prostatitis (EAP) models valuable research tools.
Current EAP models require systematic evaluation for optimal use in studying CP/CPPS.

Purpose of the Study:

To review and evaluate existing antigen-induced EAP models for CP/CPPS research.
To provide a framework for selecting appropriate EAP models for pathogenesis studies and drug screening.
To explore potential antigen-based therapeutic strategies for CP/CPPS.

Main Methods:

Comprehensive literature search on CP/CPPS and antigen-induced EAP models.
Analysis of histopathology, clinical phenotypes, and biochemical indicators in EAP models.
Evaluation of prostate and other organ function changes in EAP.

Main Results:

Multiple autoantigens identified for EAP induction, including prostate extracts (PE), p25, and T2 peptide.
While PE models are common, only T2 and p25 models replicate pelvic pain and voiding dysfunction.
PE models can exhibit fertility and mental health alterations; T2 peptide shows potential for antigen-specific therapy.

Conclusions:

Prostate extract (PE)-induced EAP is widely used, but T2 or p25 models offer superior relevance for CP/CPPS.
T2 and p25 EAP models are promising for future CP/CPPS pathogenesis and therapeutic research.
Antigen-specific therapies warrant further investigation for CP/CPPS treatment.