The other side of COVID-19 pandemic: Effects on male fertility

Area of Science:

• Reproductive biology
• Virology
• Pathology

Background:

• The COVID-19 pandemic poses a global health threat, affecting multiple organs beyond the respiratory system.
• Clinical data indicates SARS-CoV-2 can induce histopathological and functional changes in the male reproductive system.
• The renin-angiotensin system (RAS), including ACE 2 and TMPRSS2, is crucial for SARS-CoV-2 cellular entry.

Purpose of the Study:

• To investigate the potential mechanisms by which COVID-19 causes damage to the testis and male genital tract.
• To understand the impact of COVID-19 on male reproductive function.

Main Methods:

• Review of existing clinical data and scientific literature.
• Analysis of the role of ACE 2 expression in the male genital system concerning SARS-CoV-2 infection.
• Exploration of direct and indirect pathways of viral impact on male reproductive organs.

Main Results:

• The male genital system exhibits high expression of ACE 2, a key receptor for SARS-CoV-2.
• COVID-19 infection can lead to testicular damage and dysfunction.
• The pandemic has demonstrated a negative impact on male reproductive health and fertility.

Conclusions:

• SARS-CoV-2 infection poses a significant risk to male reproductive health.
• Understanding the mechanisms of COVID-19-induced male reproductive damage is critical for managing fertility issues in affected individuals.
• Further research is needed to fully elucidate the long-term consequences of COVID-19 on male fertility.