Related Experiment Video
Updated: Nov 30, 2025
Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Novel Derivatives of Nicotinic Acid as Promising Anticancer Agents
Nisha Jain1, Divya Utreja1, Komalpreet Kaur1
1Department of Chemistry, College of Basic Sciences & Humanities, Punjab Agricultural University, Ludhiana, India.
Background:
Cancer has become the second leading cause of death worldwide. Despite of the availability of significant number of anticancer agents, cancer is still incurable especially at the last stages. Remarkable targets for anticancer research and drug discovery are heterocyclic compounds, and among them, superior effect has been shown by the nitrogen containing compounds than non-nitrogen containing compounds. Nicotinic acid, a nitrogen containing moiety and its derivatives have gained an immense importance in the development of anticancer drugs owing to the wide variety of biological properties displayed by them.
Objective:
The objective of this review is to provide researchers the information about various synthetic approaches used for the synthesis of anticancer drugs of nicotinic acid from 2001 onwards and to reveal their application and importance in the treatment of this dreadful disease.
Conclusion:
As indicated by this review, considerable work has been done in terms of synthesis and investigation of anticancer potential of nicotinamide derivatives. The information provided in this article may be of great value for the researchers seeking to develop efficient anticancer drugs.
Insights
Researchers are exploring nicotinic acid derivatives for novel anticancer drugs. This review highlights synthetic methods and therapeutic applications of these nitrogen-containing compounds against cancer.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Pharmacology
Background:
- Cancer remains a leading global cause of death, necessitating novel therapeutic strategies.
- Heterocyclic compounds, particularly nitrogen-containing ones, show significant promise as anticancer agents.
- Nicotinic acid derivatives are recognized for their diverse biological activities and potential in cancer drug development.
Purpose of the Study:
- To review synthetic methodologies for nicotinic acid-based anticancer drugs developed since 2001.
- To elucidate the application and significance of these compounds in cancer treatment.
Main Methods:
- Literature review of synthetic approaches.
- Analysis of biological activities and therapeutic applications.
Main Results:
- Extensive research has focused on the synthesis and anticancer evaluation of nicotinamide derivatives.
- Various synthetic routes have been established for these compounds.
Conclusions:
- Significant progress has been made in synthesizing and investigating the anticancer potential of nicotinamide derivatives.
- This review provides valuable information for researchers developing new anticancer drugs.
Related Concept Videos
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
01:23Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
01:46Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
01:15Cholinergic Receptors: Nicotinic
There are two types of nicotinic receptors: neuromuscular (NM/NM/N1) and neuronal (NN/NN/N2). The two families differ based on their location and selectivity to...