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Related Experiment Videos

The gamma T-cell antigen receptor.

L L Lanier1, A T Serafini, J J Ruitenberg

  • 1Becton Dickinson Monoclonal Center, Inc., Mountain View, California 94043.

Journal of Clinical Immunology
|November 1, 1987
PubMed
Summary
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The gamma/delta T cell receptor (TCR) is expressed on a minor subset of lymphocytes and can mediate cytotoxicity. Its exact physiological role and ligand remain key areas for future research.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • The gamma-T cell receptor (TCR) is encoded by V, J, and C gene elements with limited recombinational diversity.
  • Gamma-TCR proteins are expressed on the lymphocyte plasma membrane with the CD3 complex, typically forming heterodimers with delta-TCR glycoproteins.
  • A minor subset of T lymphocytes expresses the gamma/delta-TCR, contrasting with the majority expressing the alpha/beta-TCR.

Purpose of the Study:

  • To investigate the nature and function of gamma/delta-TCR expressing T cells.
  • To explore the potential for gamma/delta-TCRs to mediate cytotoxicity and their relationship with CD3.
  • To identify unresolved questions regarding the physiological role and molecular properties of gamma/delta-TCR.

Main Methods:

Related Experiment Videos

  • Analysis of gamma-TCR gene rearrangement, transcription, and protein expression.
  • Characterization of gamma/delta-TCR heterodimer formation and association with CD3.
  • Establishment and functional assessment of murine and human gamma/delta T cell lines, including cytotoxicity assays.
  • Use of antibodies against CD3 or gamma-TCR to study T cell activation.

    • Main Results:

    • Gamma-TCR genes undergo rearrangement, transcription, and translation early in thymic ontogeny.
    • Both disulfide-bonded and non-disulfide-bonded gamma/delta-TCR heterodimers are found on human T lymphocytes.
    • Most established CD3, gamma/delta T cell lines exhibit cytotoxicity against tumor targets, independent of MHC.
    • Antibodies against CD3 or gamma-TCR induce proliferation, IL-2 secretion, and modulate cytotoxicity.

    Conclusions:

    • The gamma/delta-TCR functions as a receptor capable of inducing T cell activation and mediating cytotoxicity.
    • The precise ligand recognized by gamma/delta-TCR and its physiological significance remain to be elucidated.
    • Further research is needed to clarify the role of gamma/delta T lymphocytes and their relationship with alpha/beta T lymphocytes.