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Related Concept Videos

The Intrinsic Apoptotic Pathway01:31

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Related Experiment Video

Updated: Nov 30, 2025

Examining BCL-2 Family Function with Large Unilamellar Vesicles
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BCL2L13: physiological and pathological meanings.

Fei Meng1,2,3, Naitong Sun4, Dongyan Liu1,2,3

  • 1Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health & Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China.

Cellular and Molecular Life Sciences : CMLS
|November 17, 2020
PubMed
Summary

BCL2L13 protein, a BCL2-like molecule, plays dual roles in cell death and survival. Its functions in physiological processes and involvement in diseases like cancer highlight its research significance.

Keywords:
ApoptosisAutophagyBCL-ramboCerebrovascular accidentNeurodegenerative disordersTumor

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • BCL2L13 is a BCL2-like protein with diverse cellular functions.
  • Initially noted for pro-apoptotic activity, its roles are now understood to be more complex.
  • It localizes to the mitochondrial outer membrane and is expressed across various tissues.

Purpose of the Study:

  • To review the multifaceted roles of BCL2L13.
  • To explore its involvement in both physiological and pathological processes.
  • To consolidate current research on BCL2L13 for a comprehensive understanding.

Main Methods:

  • Literature review of existing studies on BCL2L13.
  • Analysis of research on BCL2L13's functions in cell death, mitochondrial dynamics, and mitophagy.
  • Synthesis of findings regarding BCL2L13's role in growth, metabolism, and diseases.

Main Results:

  • BCL2L13 exhibits context-dependent effects, capable of inducing apoptosis, inhibiting cell death, and promoting mitophagy.
  • It plays roles in physiological processes including development and energy metabolism.
  • Dysregulation of BCL2L13 is implicated in various pathologies such as cancer, infections, cardiovascular, and degenerative diseases.

Conclusions:

  • BCL2L13 is a critical regulator with dual roles in cell fate.
  • Its involvement spans normal physiological functions and disease pathogenesis.
  • BCL2L13 represents a significant area for future research and therapeutic targeting.