Giant cell reparative granuloma of the hand

A case of recurrent giant cell reparative granuloma of the hand is reported. The radiographs showed a lytic, expansile lesion that extended from the secondary ossification center proximally to the articular surface distally. Treatment consisted of excision of the involved proximal phalanx and interposition bone graft. The histopathologic findings were typical for this benign, nonneoplastic process: a cellular fibrous stroma with many giant cells. The differentiation of giant cell reparative granuloma from giant cell tumor, aneurysmal bone cyst, and brown tumor of hyperparathyroidism is reviewed.