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Viral Infections: Negative Regulators of Apoptosis and Oncogenic Factors

A V Zamaraev1, B Zhivotovsky1,2, G S Kopeina3

  • 1Faculty of Basic Medicine, Lomonosov Moscow State University, Moscow, 119192, Russia.

Biochemistry. Biokhimiia
|November 17, 2020
PubMed

Insights

Viruses can disrupt programmed cell death (apoptosis) to cause cancer. This review explores how viruses suppress apoptosis, aiding tumor development and disease progression.

Area of Science:

  • Oncology
  • Virology
  • Cell Biology

Background:

  • Disruption of programmed cell death (apoptosis) is linked to diseases like cancer.
  • Persistent viral infections are implicated in the development of various cancers.
  • Oncogenic viruses interfere with cellular apoptosis pathways.

Purpose of the Study:

  • To review mechanisms by which viruses suppress apoptosis.
  • To elucidate the role of viral apoptosis suppression in oncogenesis.

Main Methods:

  • Literature review of current data on viral apoptosis suppression and oncogenesis.

Main Results:

  • Oncogenic viruses manipulate both extrinsic and intrinsic apoptosis pathways.
  • Viruses inhibit proapoptotic proteins and signaling pathways, promoting carcinogenesis.
  • Impaired immune surveillance contributes to uncontrolled viral replication and host cell proliferation.

Conclusions:

  • Viral suppression of apoptosis is a key mechanism in cancer development.
  • Understanding these mechanisms offers insights into viral oncogenesis.

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