Applications of Convolutional Neural Networks in neurodegeneration and physiological aging

The process of aging is linked with significant changes in a human's physiological organization and structure. This is more evident in the case of the brain whose functions generally vary between young and old individuals. Detecting such patterns can be of significant importance especially during the Mild Cognitive Impairment (MCI) stage which is a transition state before the clinical onset of dementia. Intervening in that stage may delay or eventually prevent dementia onset. In this paper we propose a new methodology based in electroencephalographic (EEG) recordings, aiming to classify individuals into healthy, pathological (patients diagnosed with MCI or Mild Dementia) and young, old groups (healthy individuals over and under 50 years of age) through functional connectivity and macro-architecture features. These features are calculated on the estimated brain region activations through the inverse problem solution, enabling us to transform the sensor level EEG recordings through an appropriate transformation matrix. Afterwards, Synchronization Likelihood and Relative Wavelet Entropy values were calculated along with the graph metrics corresponding to the functional connectivity values, as well as the relative energy contributions of five EEG bands (delta, theta, alpha, beta and gamma). These features were organized in Red, Green, Blue (RGB) image-like data structures. Therefore, it was possible to classify each individual into one of the two groups per experiment employing Convolutional Neural Networks. From the maximum classification accuracy achieved on the test set, 90.48% for the pathological aging group and 91.19% for the physiological aging, it is evident that the proposed approach is capable of providing adequate health and age group classification.