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Updated: Nov 30, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

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Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs

Eva Marie Pfeil1, Julian Brands1, Nicole Merten2

  • 1Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany; Research Training Group 1873, University of Bonn, Bonn, Germany.

Molecular Cell
|November 17, 2020
PubMed

Keywords:
Ca(2+) signalingFR900359GPCRGPR17GiGqPTXheterotrimeric G proteinphospholipase Cβreal-time BRET-based IP(3) biosensor

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