Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

502
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
502
Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

126
Body:Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
126
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

99
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
99
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

3.0K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
3.0K
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

112
Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
112
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

97
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
97

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The rise of bispecific antibodies for dual targeting, singular impact: technology and clinical advancements.

International immunopharmacology·2026
Same author

Surface modified cationic PLGA microparticles as long-acting injectable carriers for intra-articular small molecule drug delivery.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2024
Same author

Biodegradable Long-Acting Injectables: Platform Technology and Industrial Challenges.

Handbook of experimental pharmacology·2023
Same author

Polyester-based long acting injectables: Advancements in molecular dynamics simulation and technological insights.

Drug discovery today·2022
Same author

Controlled Delivery of Corticosteroids Using Tunable Tough Adhesives.

Advanced healthcare materials·2022
Same author

The Dog as a Second Species for Toxicology Testing Provides Value to Drug Development.

International journal of toxicology·2022

Related Experiment Video

Updated: Nov 30, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.5K

Clinically established biodegradable long acting injectables: An industry perspective.

Christian Isalomboto Nkanga1, Andreas Fisch2, Mazda Rad-Malekshahi3

  • 1Center for Chemico- and Bio-Medicinal Research (CCBR), Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa; Faculty of Pharmaceutical Sciences, University of Kinshasa, B.P. 212, Kinshasa, XI, Democratic Republic of the Congo; Technical Research and Development, Novartis Pharma AG, Basel 4002, Switzerland.

Advanced Drug Delivery Reviews
|November 17, 2020
PubMed
Summary

Long-acting injectable formulations enhance drug delivery over extended periods. This review categorizes available systems and discusses their use in managing chronic diseases, alongside industrial development challenges.

Keywords:
Drug crystal suspensionsDrug crystalsDrug deliveryExtended releaseImplantsIn situ forming implantsLong acting injectablesMicrospheresOil-based formulationsPLGA microparticles

More Related Videos

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
04:09

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing

Published on: December 13, 2024

1.0K
PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

66.1K

Related Experiment Videos

Last Updated: Nov 30, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.5K
Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
04:09

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing

Published on: December 13, 2024

1.0K
PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

66.1K

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Biomaterials

Background:

  • Long-acting injectable formulations are designed to prolong drug efficacy within the body.
  • These advanced delivery systems serve both systemic and localized therapeutic needs.
  • Current clinical applications focus on improving patient compliance and treatment outcomes for chronic conditions.

Purpose of the Study:

  • To provide a comprehensive overview of currently available long-acting injectable drug delivery systems.
  • To categorize these systems based on their formulation types.
  • To summarize their applications in managing diverse chronic diseases and highlight associated industrial challenges.

Main Methods:

  • Review of existing literature and clinical data on long-acting injectable formulations.
  • Categorization of systems into biodegradable polymeric (microparticles, implants), micro/nanocrystal suspensions, and oil-based formulations.
  • Analysis of application data for chronic disease management and identification of development hurdles.

Main Results:

  • Long-acting injectables are classified into three primary categories: biodegradable polymeric systems, micro/nanocrystal suspensions, and oil-based formulations.
  • These formulations are effectively utilized for the management of various chronic diseases, improving therapeutic delivery.
  • Key industrial challenges in development include formulation stability, manufacturing scalability, and regulatory considerations.

Conclusions:

  • Long-acting injectable formulations represent a significant advancement in sustained drug delivery.
  • Their diverse applications offer improved management strategies for chronic diseases.
  • Addressing industrial challenges is crucial for the wider adoption and continued innovation of these technologies.