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Updated: Nov 30, 2025

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
Published on: May 4, 2017
Hypersensitivity to Rituximab in Children
Giulia Liccioli1, Gabriele Simonini2, Federico Melani3
1Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy, giulia.liccioli@meyer.it.
Abstract:
Biological agents have had an increased usage during the past years, also in pediatric population. Monoclonal antibodies can cause adverse drug reactions with different pathomechanisms, including type I IgE-mediated hypersensitivity reactions (HR). In this report, we describe 2 children who had a diagnosis of anaphylaxis to rituximab (RTX), confirmed by positive in vivo tests in both cases and elevated tryptase value in one case. We also made a review of the few cases of HR to RTX in pediatric population reported in literature and discuss differential diagnosis and utility of allergy investigations.
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