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Stability of Engineered Micro or Nanobubbles for Biomedical Applications
Beomjin Park1, Semi Yoon1, Yonghyun Choi1
1School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea.
Pharmaceutics
|November 18, 2020
Summary
Micro/nanobubbles (MNBs) show promise in medical imaging and drug delivery. This review examines factors influencing MNB stability and its impact on in vivo applications, particularly under ultrasonic fields.
Area of Science:
- Biomedical Engineering
- Materials Science
- Acoustic Physics
Background:
- Micro/nanobubbles (MNBs) are gas-filled structures with micrometer or nanometer dimensions.
- MNBs are emerging as versatile tools for angiography, drug delivery, and therapeutic applications.
- Ensuring MNB stability is crucial for their effective utilization in biomedical contexts.
Purpose of the Study:
- To review factors influencing micro/nanobubble stability.
- To analyze MNB stability under ultrasonic fields.
- To discuss the correlation between MNB stability and in vivo applicability.
Main Methods:
- Literature review focusing on MNB stability factors.
- Analysis of studies investigating MNB behavior in ultrasonic environments.
- Synthesis of findings on MNB stability and in vivo performance.
Main Results:
- Identified key factors affecting MNB stability, including size, gas composition, and surrounding medium.
- Highlighted the impact of ultrasonic fields on MNB dynamics and stability.
- Established a relationship between enhanced MNB stability and improved in vivo efficacy.
Conclusions:
- MNB stability is a critical determinant for their successful application in medicine.
- Understanding MNB behavior under ultrasound is essential for optimizing their use.
- Further research into MNB stabilization techniques will enhance their therapeutic and diagnostic potential.
