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Updated: Nov 30, 2025

Author Spotlight: Studying Cardiac Cell-Matrix Interactions In Vitro
Published on: March 22, 2024
Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair
1Department of Basic Sciences, Lawrence D. Longo, MD Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.
Abstract:
The extracellular matrix (ECM) is the non-cellular component in the cardiac microenvironment, and serves essential structural and regulatory roles in establishing and maintaining tissue architecture and cellular function. The patterns of molecular and biochemical ECM alterations in developing and adult hearts depend on the underlying injury type. In addition to exploring how the ECM regulates heart structure and function in heart development and repair, this review conducts an inclusive discussion of recent developments in the role, function, and epigenetic guidelines of the ECM. Moreover, it contributes to the development of new therapeutics for cardiovascular disease.
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