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Boronate probe-based hydrogen peroxide detection with AlGaN/GaN HEMT sensor.

Isra Mahaboob1, Roger J Reinertsen1, Benjamin McEwen1

  • 1College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.

Experimental Biology and Medicine (Maywood, N.J.)
|November 18, 2020
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Summary
This summary is machine-generated.

This study shows AlGaN/GaN high electron mobility transistor sensors can detect hydrogen peroxide, a reactive biological molecule. The sensor monitors real-time reactions using a fluorescent probe, demonstrating its dynamic measurement capabilities.

Keywords:
AlGaN/GaN HEMTHEMT sensorsHydrogen peroxideROSboronate probeelectrochemical sensing

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Area of Science:

  • Materials Science
  • Biotechnology
  • Sensor Technology

Background:

  • Reactive oxygen species, such as hydrogen peroxide, play crucial roles in intracellular signaling and oxidative stress.
  • Accurate and real-time detection of these molecules is vital for understanding biological processes and disease mechanisms.

Purpose of the Study:

  • To investigate the potential of AlGaN/GaN high electron mobility transistor (HEMT) sensors for detecting reactive biological molecules.
  • To utilize a boronate-based fluorescent probe in conjunction with the HEMT sensor for sensitive hydrogen peroxide detection.

Main Methods:

  • Fabrication and characterization of an AlGaN/GaN HEMT sensor.
  • Integration of a boronate-based fluorescent probe for hydrogen peroxide sensing.
  • Real-time monitoring of electrical signals (two-dimensional electron gas current) and fluorescence intensity during the reaction.

Main Results:

  • The AlGaN/GaN HEMT sensor successfully detected micromolar levels of hydrogen peroxide.
  • A decrease in the HEMT sensor's two-dimensional electron gas current was observed in real-time as the reaction progressed.
  • A corresponding increase in fluorescence intensity from the boronate probe confirmed hydrogen peroxide detection.

Conclusions:

  • AlGaN/GaN HEMT sensors show significant potential for detecting reactive and transient biological molecules like hydrogen peroxide.
  • The combined HEMT sensor and fluorescent probe system enables dynamic, real-time monitoring of biological reactions.
  • This technology offers a promising platform for studying reactive oxygen species in biological systems.