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Trichuris trichiura isolated from Macaca sylvanus: morphological, biometrical, and molecular study
Julia Rivero1, Ángela María García-Sánchez1, Antonio Zurita1
1Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, Professor García González 2, 41012, Seville, Spain.
BMC Veterinary Research
|November 18, 2020
Summary
This study identifies Trichuris trichiura in Macaca sylvanus using morphology and molecular data. The whipworms from these non-human primates revealed two distinct genotypes within the Trichuris trichiura lineage.
Area of Science:
- Veterinary Parasitology
- Molecular Evolution
- Primate Health
Background:
- Trichuris species complex in primates is recognized but poorly understood.
- Genetic and evolutionary links between human and non-human primate (NHP) Trichuris spp. require clarification.
- NHPs may act as reservoirs for human trichuriasis and novel Trichuris species.
Purpose of the Study:
- To morphologically, biometrically, and molecularly characterize Trichuris populations in Macaca sylvanus.
- To investigate the genetic and evolutionary relationships of Trichuris in NHPs.
- To assess the public health implications of Trichuris in primate hosts.
Main Methods:
- Morphological and biometrical analysis of whipworms.
- Principal Component Analysis (PCA).
- DNA sequencing of ribosomal (ITS2) and mitochondrial (cox1, cob) genes.
Main Results:
- Morphological and biometrical data confirmed the parasite as Trichuris trichiura.
- Phylogenetic analysis of ribosomal DNA did not resolve relationships.
- Mitochondrial DNA sequencing revealed two distinct subclades, indicating molecular differentiation within Trichuris trichiura in M. sylvanus.
Conclusions:
- Morphological, biometrical, and molecular data confirm Trichuris trichiura in Macaca sylvanus.
- Two distinct genotypes of Trichuris trichiura were identified within the M. sylvanus population.
- Further research on host range, evolution, and phylogeography of Trichuris trichiura is crucial due to its public health significance.
