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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Methods of reducing fever01:22

Methods of reducing fever

1.0K
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
1.0K
Cancer Therapies02:49

Cancer Therapies

9.3K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

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As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
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Related Experiment Video

Updated: Nov 30, 2025

Protocol for Long Duration Whole Body Hyperthermia in Mice
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Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

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Emerging hyperthermia applications for pediatric oncology.

Caitlin Tydings1, Karun V Sharma2, AeRang Kim3

  • 1Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, United States of America; Oncology, Children's National Medical Center, Washington, DC, United States of America.

Advanced Drug Delivery Reviews
|November 18, 2020
PubMed
Summary

Hyperthermia, a heat-based cancer treatment, shows promise in pediatric oncology. It can enhance chemotherapy, radiation, and immunotherapy, offering a vital option where other treatments reach limits.

Keywords:
Ablative hyperthermiaAdjuvant therapyDrug deliveryImmunotherapyMR-HIFUMRgHIFUMicrowave ablationMild hyperthermiaPediatric oncologyRFATherapeutic ultrasoundThermal ablation

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Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
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Area of Science:

  • Oncology
  • Immunology
  • Thermotherapy

Background:

  • Hyperthermia impacts the tumor microenvironment and host immune system.
  • Ablative hyperthermia (>55°C) is used as monotherapy or adjuvant therapy.
  • Mild hyperthermia (39-45°C) enhances chemotherapy and radiation therapy.

Purpose of the Study:

  • Review current applications of hyperthermia in pediatric oncology.
  • Discuss hyperthermia's role alongside other cancer treatments.
  • Explore hyperthermia's potential to boost immunotherapy.

Main Methods:

  • Literature review of hyperthermia applications in pediatric oncology.
  • Analysis of hyperthermia's effects on tumor microenvironment and immune response.
  • Synthesis of pre-clinical research and clinical integration data.

Main Results:

  • Mild hyperthermia effectively enhances chemotherapy and radiation therapy.
  • Hyperthermia activates local and systemic immune responses.
  • Pediatric oncology benefits from hyperthermia due to chemotherapy tolerance limits and late effect risks.

Conclusions:

  • Hyperthermia offers a promising therapeutic strategy in pediatric oncology.
  • Combining hyperthermia with chemotherapy, radiation, or immunotherapy may improve outcomes.
  • Further research into hyperthermia's integration is warranted for pediatric cancer patients.