Related Experiment Video

Updated: Nov 29, 2025

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

9.2K

The Inflammatory Aspect of Male and Female Pattern Hair Loss

Nadia Peyravian1, Sapna Deo1, Sylvia Daunert1

  • 1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA.

Journal of Inflammation Research
|November 18, 2020
PubMed

Insights

Inflammation plays a key role in male and female pattern hair loss (MPHL and FPHL). Understanding this inflammatory aspect could lead to new and more effective hair loss treatments.

Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Male and female pattern hair loss (MPHL and FPHL) are common conditions affecting millions.
  • Current treatment options for MPHL and FPHL are limited and often ineffective.

Purpose of the Study:

  • To highlight the inflammatory aspect of MPHL and FPHL pathogenesis.
  • To explore the potential of targeting inflammation for novel therapeutic strategies.

Main Methods:

  • Review of clinical and quantitative data on MPHL and FPHL.
  • Evaluation of inflammatory infiltrates and gene involvement.

Main Results:

  • Significant perifollicular inflammatory infiltrates, including lymphocytes and histiocytes, are present in MPHL and FPHL.
  • Involvement of inflammatory genes such as CASP7 and TNF is observed in MPHL and FPHL.

Conclusions:

  • Inflammation is a critical characteristic of MPHL and FPHL.
  • Focusing on the inflammatory pathways could significantly advance the development of new treatments for hair loss.

Keywords:
female pattern baldnesshair lossinflammationmale pattern baldness

More Related Videos

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia03:22

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

Published on: January 27, 2018

15.4K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.9K

Related Concept Videos

Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
2.1K
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
3.4K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.0K
Accessory Structures of the Skin: Hair and Hair Follicles01:16

Accessory Structures of the Skin: Hair and Hair Follicles

Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
3.9K
Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
430
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.8K