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Regulating DSC2 Expression Affects the Proliferation and Apoptosis of Prostate Cancer Cells

Feng Jiang1, Pengfei Wu2

  • 1Department of Urology, Shanghai Pudong New Area People's Hospital, Shanghai 201200, People's Republic of China.

Cancer Management and Research
|November 18, 2020
PubMed
Abstract

Insights

Desmocollin-2 (DSC2) is elevated in prostate cancer. Inhibiting DSC2 boosts cancer cell growth and spread while reducing cell death, offering potential therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • Prostate cancer is a significant health concern for men.
  • Desmocollin-2 (DSC2), a member of the DSC family, is implicated in tumor cell invasion and metastasis.

Purpose of the Study:

  • To investigate the role of DSC2 in prostate cancer progression.

Main Methods:

  • DSC2 expression was manipulated in prostate cancer cell lines.
  • Western blot analysis was used to assess protein expression.
  • Cell proliferation, clone formation, migration, invasion, and apoptosis were evaluated using various assays.

Main Results:

  • DSC2 expression was higher in prostate cancer cells than in normal cells.
  • Inhibiting DSC2 increased proliferation, migration, and invasion while decreasing apoptosis.
  • DSC2 inhibition altered apoptosis and cell cycle-related protein expression, affecting the E-cadherin/β-catenin pathway.

Conclusions:

  • DSC2 is upregulated in prostate cancer.
  • Inhibiting DSC2 promotes prostate cancer cell proliferation and metastasis, suggesting DSC2 as a potential therapeutic target.
Keywords:
DSC2apoptosisproliferationprostate cancer cell

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