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Related Experiment Video

Updated: Nov 29, 2025

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

Progress in Stem Cell Therapy for Spinal Cord Injury.

Liansheng Gao¹, Yucong Peng¹, Weilin Xu¹

¹Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Stem Cells International

|November 18, 2020

Summary

Stem cell (SC) therapy shows promise for treating spinal cord injury (SCI), with various cell types and delivery methods demonstrating potential benefits. Further research and clinical trials are needed to optimize safety and efficacy for this debilitating condition.

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Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

Area of Science:

Neuroscience and Regenerative Medicine
Cell Biology and Therapeutics

Background:

Spinal cord injury (SCI) is a severe neurological condition with limited effective treatments.
Stem cell (SC) therapy has emerged as a significant research focus for SCI over recent decades.

Purpose of the Study:

To review the research progress of stem cell (SC) therapy for spinal cord injury (SCI).
To summarize the effects, strategies, mechanisms, safety, and clinical applications of different SC types and novel approaches in SCI treatment.

Main Methods:

Literature review and synthesis of existing studies on SC therapy for SCI.
Analysis of various SC types (MSCs, HSCs, NSCs, iPSCs, ESCs) and their therapeutic strategies.
Evaluation of treatment modalities, transplantation pathways, cell dosages, and emerging technologies.

Main Results:

Numerous studies indicate positive effects of SC therapy for SCI, utilizing diverse cell types and administration routes (intravenous, intrathecal, etc.).
Potential therapeutic mechanisms include tissue repair, neurotrophy, regeneration, angiogenesis, anti-apoptosis, and anti-inflammatory effects.
Identified safety concerns include thrombosis, tumorigenicity, infection, and fever, highlighting the need for careful consideration.

Conclusions:

While most studies support SC therapy for SCI, variations in cell types, mechanisms, and strategies exist.
Safety considerations are paramount, and further clinical trials are essential for validating efficacy and safety.
Integration of new technologies holds significant potential for advancing SC therapy in SCI treatment.