Related Experiment Video
Updated: Nov 29, 2025
Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
Published on: July 10, 2018
Effects of Sublingual Duster Mite Drops on Lung Function and Exhaled Nitric Oxide in Children with Multiple and
Li Wang1, Tao Ai1, Ronghua Luo1
1Pediatric Respiratory Medicine Department, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China.
Insights
Sublingual immunotherapy with Dermatophagoides Farinae Drops effectively improved symptoms and lung function in children with single and multiple respiratory allergies. This treatment offers a viable option for managing pediatric allergic respiratory diseases.
Area of Science:
- Allergy and Immunology
- Pediatric Respiratory Medicine
- Immunotherapy
Background:
- Respiratory allergic diseases are common in children.
- Sublingual immunotherapy (SLIT) is an alternative to traditional allergy treatments.
- Dermatophagoides Farinae is a common allergen implicated in respiratory allergies.
Purpose of the Study:
- To evaluate the efficacy of SLIT using Dermatophagoides Farinae Drops in children.
- To compare outcomes in children with single versus multiple respiratory allergic diseases.
Main Methods:
- Seventy-one children with allergic respiratory diseases received Dermatophagoides Farinae Drops for over one year.
- Patients were categorized into single (12) and multiple (59) allergic groups.
- Evaluated outcomes included rhinitis score, asthma symptoms, VAS score, drug use, pulmonary function, and fractional exhaled nitric oxide (FeNO).
Main Results:
- Significant reductions in rhinitis, VAS, and drug scores were observed in both groups post-treatment (p < 0.05).
- Pulmonary function improved significantly, and FeNO levels decreased significantly in both groups (p < 0.05).
- No significant differences in outcomes were found between the single and multiple allergic groups.
Conclusions:
- Sublingual immunotherapy with Dermatophagoides Farinae Drops is effective for pediatric allergic respiratory diseases.
- The treatment demonstrates efficacy in both single and multiple allergic conditions.
- SLIT offers a beneficial therapeutic option for children suffering from allergic respiratory ailments.
Objective:
To evaluate the efficiency of sublingual immunotherapy with Dermatophagoides Farinae Drops in children with single and multiple respiratory allergic diseases.
Methods:
Seventy-one children with allergic respiratory diseases who had been treated with Dermatophagoides Farinae Drops for one year or more were divided into a single allergic group (12 cases) and multiple allergic group (59 cases). The rhinitis score, daytime and night symptom score of asthma, VAS score, drug score, pulmonary function, and FeNO level before and after treatment were evaluated and compared between the two groups.
Results:
The rhinitis score, night symptom score, VAS score, and drug score in the single allergic group after treatment were significantly lower than those before treatment (p < 0.05), but there was no significant difference in the daytime symptom score before and after treatment (p > 0.05). The rhinitis score, VAS score, and drug score in the multiple allergic group after treatment were significantly lower than those before treatment (p < 0.05), but there was no significant difference in the scores of daytime symptoms and nighttime symptoms before and after treatment (p > 0.05). In both the single allergic group and multiple allergic group, the pulmonary function indexes of the patients were significantly improved after treatment, and the FeNO after treatment was significantly lower than that before treatment (p < 0.05). There was no significant difference in scores, pulmonary function, and FeNO between the two groups (p > 0.05).
Conclusion:
Sublingual specific immunotherapy is effective in treating multiple and single allergic respiratory diseases in children.
Related Concept Videos
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
01:17Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
01:23Inhaled Medications
01:24Antiasthma Drugs: Methylxanthines
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...