Related Experiment Video
Updated: Nov 29, 2025
04:34
Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
Published on: September 14, 2018
26.2K
World allergy organization anaphylaxis guidance 2020
Victoria Cardona1, Ignacio J Ansotegui2, Motohiro Ebisawa3
1Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron, and ARADyAL research network, Barcelona, Spain.
The World Allergy Organization Journal
|November 18, 2020
Summary
Anaphylaxis, a severe allergic reaction, requires updated management guidelines. Epinephrine remains the first-line treatment, but its use is suboptimal, highlighting the need for better patient education and access to epinephrine auto-injectors.
Area of Science:
- Allergy and Immunology
- Emergency Medicine
- Clinical Practice Guidelines
Background:
- Anaphylaxis, a severe systemic allergic reaction, is increasing.
- Current knowledge on anaphylaxis diagnosis and management requires dissemination among healthcare professionals.
- Existing 2011 World Allergy Organization (WAO) guidelines need updating.
Purpose of the Study:
- To update clinical guidance for anaphylaxis management.
- To align recommendations with the current state of knowledge.
- To address suboptimal epinephrine use and access issues.
Main Methods:
- Review and update of existing anaphylaxis management guidelines.
- Incorporation of novel changes based on current scientific evidence.
- Focus on first-line treatment, post-reaction care, and access to medication.
Main Results:
- Intramuscular epinephrine (adrenaline) remains the recommended first-line treatment for anaphylaxis.
- Epinephrine use in anaphylaxis is suboptimal.
- Referral to specialists for cause assessment, prevention, and self-management education is crucial.
- Limited availability and affordability of epinephrine auto-injectors are significant global challenges.
Conclusions:
- Updated guidelines reinforce epinephrine as the primary treatment for anaphylaxis.
- Improved healthcare professional preparedness and patient education are essential.
- Addressing systemic issues of epinephrine auto-injector availability and affordability is critical for effective anaphylaxis management.
Keywords:
ACE, Angiotensin converting enzymeAcute systemic allergic reactionAdrenalineAnaphylaxisAntihistaminesBAT, basophil activation testCAST, cellular allergen stimulation testCofactorsDrug allergyEAI, epinephrine auto-injectorsEpinephrineFcεRI, IgE high-affinity receptorFood allergyGlucocorticoidsGuidanceGuidelinesIgE, immunoglobulin EIgG, immunoglobulin GMRGPRX2, Mas-related G-protein coupled receptor member X2NSAIDs, nonsteroidal anti-inflammatory drugsVenom allergy
