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The Relationship between Serum Vitamin C and Uric Acid Levels, Antioxidant Status and Coronary Artery Disease: a

Aida Torkzaban1, Amirmansour Alavi Naeini1, Akbar Hassanzadeh2

  • 1Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.

Clinical Nutrition Research
|November 18, 2020
PubMed

Insights

Elevated uric acid and reduced vitamin C levels are linked to coronary artery disease (CAD). This study found these markers, but not overall antioxidant capacity, differed significantly between CAD patients and healthy individuals.

Area of Science:

  • Cardiology
  • Biochemistry
  • Nutritional Science

Background:

  • Coronary artery disease (CAD) is a leading cause of adult mortality.
  • Oxidative stress and impaired antioxidant defense contribute to atherosclerosis progression.
  • Understanding the role of specific antioxidants like uric acid and vitamin C in CAD is crucial.

Purpose of the Study:

  • To compare serum levels of uric acid (UA) and vitamin C in CAD patients versus healthy controls.
  • To assess and compare the total antioxidant capacity (TAC) and malondialdehyde (MDA) levels.
  • To investigate the association between these markers and CAD risk.

Main Methods:

  • A case-control study involving 44 CAD patients and 44 healthy controls.
  • Collection of demographic, anthropometric, dietary (FFQ), and physical activity (IPAQ) data.
  • Measurement of serum UA, vitamin C, TAC, and MDA levels after overnight fasting.

Main Results:

  • CAD patients showed significantly higher serum uric acid and lower serum vitamin C levels compared to controls.
  • No significant differences were found in serum MDA or TAC levels between the groups.
  • Dietary intake of certain vitamins and minerals did not significantly differ, except for vitamin C intake.

Conclusions:

  • Increased serum uric acid and decreased serum vitamin C may be risk factors for coronary artery disease.
  • The study suggests a potential role for UA and vitamin C in CAD pathogenesis.
  • Further research with larger sample sizes is required to clarify the relationship between TAC and CAD risk.

Keywords:
Ascorbic acidAtherosclerosisCoronary artery diseaseUric acid

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