A comparison of Sysmex-XN 2000 and Yumizen H2500 automated hematology analyzers

A complete blood count is a highly automated laboratory test. The use of highly advanced measurement methods increases the accuracy and sensitivity of the determination of individual hematological parameters, especially in the case of white blood cells differentiation. Therefore, it is necessary to make comparative analyses, which involve performance of the analyzers used in daily work. The aim of the study was to indicate whether the results obtained using two compared analyzers show significant differences.

In this study a comparative analysis of 241 peripheral blood samples from adult patients was performed. The complete blood count results were obtained using two automated hematology analyzers: Sysmex XN-2000 and Horiba Yumizen H2500. The Passing-Bablok regression method and Bland- Altman analysis were also used to evaluate the results received for both analyzers.

Statistically significant differences were found for four hematological parameters: eosinophil count, immature granulocytes, mean corpuscular hemoglobin concentration (MCHC) and platelet distribution width (PDW). The P value for MCHC was 0.01. Sysmex XN-2000 and Horiba Yumizen H2500 also showed disagreement in plate platelet distribution width (PDW) (P ​= ​0.04). For other parameters both analyzers showed good agreement.

Based on the results of the study, it was shown that there are significant differences in the measurements of hematological parameters between compared analyzers.