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Novel oral anticoagulants in intracardiac thrombosis resolution: a case series

Mohammed Al-Sadawi1, Jonathan Francois1, Romy Rodriguez Ortega1

  • 1Department of Internal Medicine, SUNY Downstate, 450 Clarkson Ave Box 1199, Brooklyn, NY 11203, USA.

European Heart Journal. Case Reports
|November 18, 2020
PubMed

Insights

Direct oral anticoagulants (DOACs) show promise for treating intracardiac thrombosis, offering potential for superior thrombus resolution compared to traditional therapies. This study supports DOACs as an effective option for left atrial appendage thrombi.

Area of Science:

  • Cardiology
  • Hematology
  • Pharmacology

Background:

  • Vitamin K antagonists (VKAs) have historically been the standard treatment for intracardiac thrombosis, primarily based on observational data.
  • Direct oral anticoagulants (DOACs) are now first-line for many thrombotic conditions, but their role in intracardiac thrombosis is still evolving.
  • Emerging evidence suggests DOACs may be effective, potentially offering better thrombus resolution than warfarin.

Purpose of the Study:

  • To evaluate the efficacy of direct oral anticoagulants (DOACs) in treating left atrial appendage thrombi.
  • To contribute to the growing body of evidence supporting DOACs for intracardiac thrombosis.

Main Methods:

  • A case series of six patients with left atrial appendage thrombi was analyzed.
  • Patients were treated with a standard venous thromboembolic dose of DOACs.

Main Results:

  • Complete resolution of left atrial appendage thrombi was observed in all six patients.
  • Thrombus resolution occurred within a 2-6 month treatment period.
  • No complications were reported during the treatment course.

Conclusions:

  • This case series supports the use of DOACs as an effective treatment for intracardiac thrombi.
  • DOACs represent a viable alternative for managing left atrial appendage thrombosis.
Abstract

Keywords:
Case seriesDOACIntracardiac thrombosisOral anticoagulants

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