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Alpha-chloralose as a canine anesthetic
H H Holzgrefe1, J M Everitt, E M Wright
1Cardiovascular Diseases Research Laboratory, Upjohn Company, Kalamazoo, MI.
Laboratory Animal Science
|October 1, 1987
Summary
Alpha-chloralose is a widely used animal anesthetic, particularly in cardiovascular studies. However, its classification as a true anesthetic versus a sedative agent remains debated, impacting ethical considerations in animal research.
Area of Science:
- Pharmacology
- Neuroscience
- Veterinary Anesthesia
Background:
- Alpha-chloralose, first described in 1893, exhibits potent central nervous system (CNS) activity.
- While toxic for human therapeutic use, it is a common laboratory animal anesthetic.
Purpose of the Study:
- To review the pharmacologic profile and applications of alpha-chloralose.
- To address the controversy surrounding its anesthetic versus sedative properties in animal research.
Main Methods:
- Literature review of studies involving alpha-chloralose.
- Analysis of its use in animal models, especially in cardiovascular research.
Main Results:
- Alpha-chloralose is a frequently used anesthetic in acute cardiovascular studies, second only to sodium pentobarbital.
- Its efficacy is noted where myocardial function preservation is critical.
Conclusions:
- The classification of alpha-chloralose as a true anesthetic or a sedative agent is debated.
- This distinction has significant implications for ethical animal research practices.