Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

1.3K
A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
1.3K
Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

516
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
516
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

8.6K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Triple-Pulse <sup>23</sup>Na MRI Sequence (TriNa) for Simultaneous Acquisition of Spin-Density-Weighted and Fluid-Attenuated Images.

Magnetic resonance in medicine·2026
Same author

Exploring fMRI-neurofeedback to reduce craving-related brain activity in people with cannabis use disorder: A feasibility study.

Addictive behaviors·2026
Same author

Bed nucleus of the stria terminalis connectivity during food cue and taste processing under stress.

Nature communications·2026
Same author

From Offline to Inline Without Pain: A Practical Framework for Translating Offline MR Reconstructions to Inline Deployment Using the Gadgetron Platform.

Magnetic resonance in medicine·2026
Same author

Brain Morphology and Quantitative Assessment of Sensory Brain Areas in Southern Bluefin Tuna, Thunnus maccoyii (Scombridae, Teleostei).

The Journal of comparative neurology·2026
Same author

SynPoC: a high-quality generative diffusion model for transforming ultra-low-field point-of-care MRI using high-field MRI representations.

Scientific reports·2026

Related Experiment Video

Updated: Nov 29, 2025

Cardiac Magnetic Resonance Imaging at 7 Tesla
09:14

Cardiac Magnetic Resonance Imaging at 7 Tesla

Published on: January 6, 2019

11.9K

Ultra-high-field MRI using composite RF (STEP) pulses.

Roger Ordidge1, Jon Cleary1, Rebecca Glarin1

  • 1Melbourne Brain Centre Imaging Unit, University of Melbourne, Australia.

NMR in Biomedicine
|November 18, 2020
PubMed
Summary

New serial transmit excitation pulses (STEP) mitigate radiofrequency field non-uniformity in ultra-high field MRI. This advance addresses key technical challenges for 7 Tesla and higher magnetic resonance imaging applications, particularly in brain imaging.

Keywords:
B0 inhomogeneity correctionB1 inhomogeneity correctionRF pulse designbrain imagingother applicationsultra-high field

More Related Videos

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
10:06

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

Published on: May 10, 2012

13.2K
Author Spotlight: Optimized Lung MRI Protocol with Computationally Efficient Reconstruction Methods
05:07

Author Spotlight: Optimized Lung MRI Protocol with Computationally Efficient Reconstruction Methods

Published on: September 6, 2024

595

Related Experiment Videos

Last Updated: Nov 29, 2025

Cardiac Magnetic Resonance Imaging at 7 Tesla
09:14

Cardiac Magnetic Resonance Imaging at 7 Tesla

Published on: January 6, 2019

11.9K
High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
10:06

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

Published on: May 10, 2012

13.2K
Author Spotlight: Optimized Lung MRI Protocol with Computationally Efficient Reconstruction Methods
05:07

Author Spotlight: Optimized Lung MRI Protocol with Computationally Efficient Reconstruction Methods

Published on: September 6, 2024

595

Area of Science:

  • Medical Imaging
  • Magnetic Resonance Imaging Physics
  • Radiofrequency Pulse Design

Background:

  • Ultra-high field (UHF) magnetic resonance imaging (MRI) presents significant potential for expanded clinical and research applications.
  • Technical hurdles, particularly radiofrequency (RF) field (B1) non-uniformity, limit the full realization of UHF MRI benefits at 7 Tesla (T) and above.
  • Subject-induced B1 inhomogeneity is a major challenge in UHF MRI, especially for imaging complex anatomy like the human brain.

Purpose of the Study:

  • To introduce and evaluate novel composite RF pulse techniques for mitigating B1 field non-uniformity in UHF MRI.
  • To explore the efficacy of serial transmit excitation pulses (STEP) as an alternative to parallel transmission techniques.
  • To demonstrate the application and performance of STEP sequences in human brain imaging at ultra-high field strengths.

Main Methods:

  • Development and implementation of new variations of serial transmit excitation pulses (STEP).
  • Comparison of STEP sequences against traditional parallel pulse techniques for B1 field correction.
  • Application and evaluation of STEP sequences in human brain imaging protocols at ultra-high field strengths.

Main Results:

  • STEP sequences effectively mitigate the effects of non-uniform B1 excitation fields caused by subject-specific anatomy.
  • The proposed STEP techniques demonstrate improved RF field homogeneity compared to conventional methods in human brain imaging.
  • Evaluation confirms the practical applicability of STEP for enhancing image quality in 7T and higher MRI.

Conclusions:

  • Serial transmit excitation pulses (STEP) offer a promising solution for addressing B1 inhomogeneity in ultra-high field MRI.
  • STEP techniques represent a viable alternative to parallel transmission for improving RF excitation accuracy.
  • The successful application in human brain imaging highlights the potential of STEP for advancing UHF MRI technology.