Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

2.4K
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biodegradable Synthetic Graft with Sustained Hydrogen Sulfide Release Promotes Endothelial Cell Growth.

Macromolecular bioscience·2025
Same author

Photocurable and 3D Printable Functional Polyesters to Engineer Elastomeric Scaffolds for Biomedical Applications.

Macromolecular bioscience·2025
Same author

Development of a Microphysiological System to Model Human Cancer Metastasis From the Colon to the Liver.

Biotechnology and bioengineering·2024
Same author

Pair of Functional Polyesters That Are Photo-Cross-Linkable and Electrospinnable to Engineer Elastomeric Scaffolds with Tunable Structure and Properties.

ACS applied bio materials·2024
Same author

Three-Dimensional Printing of Poly(glycerol sebacate) Acrylate Scaffolds <i>via</i> Digital Light Processing.

ACS applied bio materials·2022
Same author

Using Solution Electrowriting to Control the Properties of Tubular Fibrous Conduits.

ACS biomaterials science & engineering·2021

Related Experiment Video

Updated: Nov 29, 2025

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
11:17

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

Published on: January 19, 2016

22.7K

Citrate Crosslinked Poly(Glycerol Sebacate) with Tunable Elastomeric Properties.

Brandon B Risley1, Xiaochu Ding1,2, Ying Chen1

  • 1Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, 277 Kimball Hall, 134 Hollister Drive, Ithaca, NY, 14853, USA.

Macromolecular Bioscience
|November 18, 2020
PubMed
Summary

Poly(glycerol sebacate citrate) (PGSC) elastomers offer tunable properties for tissue engineering. Citric acid crosslinking creates a faster, more elastic material with good biocompatibility, suitable for biomedical applications.

Keywords:
biomaterialcitric acidelastomerspoly(glycerol sebacate)thermal crosslinking

More Related Videos

Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites
12:21

Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites

Published on: February 6, 2016

13.2K
Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

12.9K

Related Experiment Videos

Last Updated: Nov 29, 2025

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
11:17

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

Published on: January 19, 2016

22.7K
Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites
12:21

Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites

Published on: February 6, 2016

13.2K
Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

12.9K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Poly(glycerol-sebacate) (PGS) is a biocompatible elastomer for soft tissue engineering.
  • Current PGS fabrication requires harsh thermal crosslinking conditions.

Purpose of the Study:

  • To investigate citric acid as a crosslinker for poly(glycerol-sebacate) (PGS) to form poly(glycerol sebacate citrate) (PGSC) elastomers.
  • To evaluate the impact of citrate content and curing time on PGSC properties.

Main Methods:

  • Synthesis of PGSC elastomers with varying citrate concentrations and curing durations.
  • Mechanical property testing (tensile strength, elasticity).
  • Degradation studies, hydrophilicity measurements, and material acidity monitoring.
  • In vitro cytocompatibility assessment using human umbilical vein endothelial cells.

Main Results:

  • PGSC elastomers exhibit tunable mechanical properties and enhanced elasticity compared to PGS.
  • Low citrate content and short curing times yield desirable PGSC characteristics.
  • Materials show good cytocompatibility with endothelial cells.
  • Acidity correlates with citrate content and curing time, indicating potential unreacted citric acid.

Conclusions:

  • PGSC is a promising biodegradable elastomer for biomedical applications.
  • Citric acid facilitates faster thermal crosslinking and tunable elastomeric properties.
  • PGSC demonstrates potential for large-scale soft tissue engineering applications.