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Stable fiber-based polarization-sensitive optical coherence tomography using polarization maintaining common-path

Peijun Tang1, Ruikang Wang1

  • 1Univ. of Washington, United States.

Journal of Biomedical Optics
|November 18, 2020
PubMed
Summary

This study presents a stable fiber-based polarization-sensitive optical coherence tomography (PS-OCT) system. The novel design overcomes environmental disturbances, enabling reliable polarization measurements for biological imaging.

Keywords:
biomedical imagingoptical coherence tomographyoptics fiberpolarization

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Area of Science:

  • Biomedical Optics
  • Optical Imaging
  • Biophotonics

Background:

  • Fiber-based polarization-sensitive optical coherence tomography (PS-OCT) offers unique insights into biological samples.
  • Environmental disturbances to optical fibers disrupt the polarization state, challenging traditional PS-OCT stability and clinical translation.

Purpose of the Study:

  • To develop a stable fiber-based PS-OCT system immune to environmental perturbations.
  • To ensure the output polarization state remains stable for reliable measurements.

Main Methods:

  • Fabrication of a polarization-maintaining common-path (CP) interferometer.
  • Integration of polarization-maintaining (PM) fibers to preserve light polarization states.
  • Utilizing the shared CP in sample and reference arms to eliminate phase variations.

Main Results:

  • Demonstrated a stable fiber-based PS-OCT system by combining PM fibers and a CP interferometer.
  • Validated system stability under periodic fiber stress.
  • Acquired stable in vivo PS-OCT images of mouse thigh tissue.

Conclusions:

  • A stable fiber-based PS-OCT system was successfully developed.
  • The combined PM fiber and CP configuration effectively stabilizes output polarization.
  • The system maintains stable performance and sensitivity despite environmental disturbances, supporting clinical applications.