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Age-Related Changes in the Canine Aorta.
170728The Ohio State University, Columbus, OH, USA.
Veterinary Pathology
|November 18, 2020
Summary
Age-related aortic changes in dogs include intimal thickening and medial fibrosis. Differentiating these common histologic findings from specific diseases is crucial for accurate veterinary diagnosis.
Area of Science:
- Veterinary Pathology
- Cardiovascular Histology
- Comparative Pathology
Background:
- Aortic degenerative changes are common in aging dogs and humans.
- Age-related changes can resemble lesions from genetic or degenerative diseases.
- Accurate differentiation is vital for diagnosticians.
Purpose of the Study:
- To evaluate age-related histologic changes in canine aortas.
- To establish criteria for distinguishing age-related changes from specific diseases.
Main Methods:
- Histologic evaluation of aortas from 37 clinically healthy dogs (2 months to 15 years).
- Categorization into three age cohorts.
- Application of standardized nomenclature and diagnostic criteria adapted from human literature.
Main Results:
- Increased scores for intimal thickening, translamellar medial fibrosis, smooth muscle cell loss, and medial microcalcification in older dogs.
- No significant age difference in mucoid extracellular matrix accumulation (cystic medial necrosis).
- Older dogs showed higher prevalence of translamellar medial fibrosis and medial microcalcification.
Conclusions:
- A spectrum of age-related aortic histologic changes exists in dogs.
- Signalment and clinical data integration aids in differentiating age-related findings from disease processes.
Keywords:
aortachondro-osseous metaplasiacystic medial degenerationdegenerative diseasesdogshistopathologymicrocalcificationmucoid extracellular matrix accumulationvascular diseasesMore Related Videos
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