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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
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[Postoperative cognitive disorder].

E A Lyashenko1, L G Ivanova2, A Sh Chimagomedova1

  • 1Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|November 18, 2020
PubMed
Summary
This summary is machine-generated.

Postoperative cognitive dysfunction (POCD) affects 40% of older adults after surgery. This review covers POCD

Keywords:
cerebrolysindeliriumdementiapostoperative cognitive disorder

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Area of Science:

  • Geriatric Medicine
  • Neuroscience
  • Anesthesiology

Background:

  • Postoperative cognitive dysfunction (POCD) affects approximately 40% of elderly patients undergoing surgery.
  • The aging global population is increasing the incidence of POCD, presenting a significant medical and social challenge.
  • Addressing POCD requires a coordinated, multidisciplinary approach involving anesthesiology, surgery, neurology, psychiatry, neuropsychology, and fundamental neurosciences.

Purpose of the Study:

  • To provide a comprehensive overview of the pathogenesis, prevention, and treatment of postoperative cognitive dysfunction (POCD).
  • To highlight the necessity of a systematic, multidisciplinary strategy for managing POCD in elderly patients.

Main Methods:

  • Literature review focusing on the multifaceted aspects of POCD.
  • Analysis of contributing factors from various medical and scientific disciplines.
  • Synthesis of current knowledge on POCD pathogenesis, prevention, and treatment strategies.

Main Results:

  • POCD is a prevalent complication in elderly surgical patients.
  • The complexity of POCD necessitates an integrated approach across multiple specialties.
  • Understanding the pathogenesis is crucial for developing effective prevention and treatment interventions.

Conclusions:

  • A multidisciplinary approach is essential for effectively managing POCD.
  • Further research into the pathogenesis of POCD will inform better prevention and treatment strategies.
  • Addressing POCD is critical for improving outcomes in the aging surgical population.