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Updated: Nov 29, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Building trans-bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: the case for antibiotic

Wanli Zhang1, Anna R Kaplan1, Emma K Davison2

  • 1Department of Chemistry, Emory University, USA. wwuest@emory.edu.

Natural Product Reports
|November 18, 2020
PubMed
Summary

Natural products with trans-bicyclo[4.4.0]decane/decene scaffolds show potent antibacterial activity. Efficient synthesis of these complex molecules is key to developing new antibiotics to combat resistance.

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