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MiR-24-3p as a prognostic indicator for multiple cancers: from a meta-analysis view
He Wang1, Chunyang Chen1, Keke Ding1
1Department of Urology, First Affiliated Hospital of Soochow University, 188 Shizi RD, Suzhou 215006, China.
Bioscience Reports
|November 18, 2020
Summary
Elevated microRNA-24-3p (miR-24-3p) expression is linked to worse cancer outcomes, including reduced overall survival and recurrence-free survival. This finding suggests miR-24-3p may be a biomarker for predicting poor prognosis in cancer patients.
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Discovery
Background:
- MicroRNAs (miRNAs) are implicated as oncogenes or tumor suppressors in various cancers.
- miR-24-3p is a frequently studied miRNA, but its prognostic significance remains debated.
Purpose of the Study:
- To conduct a meta-analysis evaluating the prognostic value of miR-24-3p across different cancer types.
- To assess the association between miR-24-3p expression and patient survival and clinicopathological features.
Main Methods:
- Systematic literature search of PubMed, Embase, Web of Science, and Cochrane Library (up to March 2020).
- Meta-analysis of 15 studies (14 publications) using Hazard Ratios (HRs) and Odds Ratios (ORs).
- Fixed-effects model applied for survival analysis (overall survival, recurrence-free survival, disease-free survival).
Main Results:
- Higher miR-24-3p expression correlated with significantly worse overall survival (OS).
- Elevated miR-24-3p levels were significantly associated with shorter recurrence-free survival (RFS) and disease-free survival (DFS).
- Increased miR-24-3p was linked to larger tumor size (≥5 cm) and advanced TNM stages (III-IV).
Conclusions:
- Elevated miR-24-3p expression may serve as a promising biomarker for predicting poor cancer prognosis.
- miR-24-3p's role in cancer progression warrants further investigation.
- This meta-analysis provides robust evidence for miR-24-3p as a prognostic indicator.
