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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Respiratory Assessment: Purpose and Indications01:19

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Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
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Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

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Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
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Hypoxia01:23

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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
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Pneumothorax-II01:27

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Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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Hyperbaric oxygen and radiation therapy: a review.

E Fernández1, V Morillo2, M Salvador3

  • 1Radiation Oncology Service, Provincial Hospital of Castellón, Avda. Dr. Clara 19, 12002, Castellón de la Plana, Spain. enc.fcam@gmail.com.

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|November 18, 2020
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Hyperbaric oxygen therapy (HBOT) can treat radiation injuries and potentially enhance radiotherapy effectiveness. Evidence suggests HBOT reduces late toxicity and improves tumor control, especially for head and neck cancers.

Keywords:
CancerHyperbaric oxygen therapyRadio-sensitizationRadiotoxicity

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Area of Science:

  • Oncology
  • Radiotherapy
  • Hyperbaric Medicine

Background:

  • Severe late-onset toxicity affects approximately 5% of cancer patients post-radiotherapy.
  • Hyperbaric oxygen therapy (HBOT) is a recognized treatment for radiation injuries, supported by historical case studies.
  • Tumor hypoxia correlates with radioresistance, suggesting oxygenation could improve radiotherapy outcomes.

Purpose of the Study:

  • To review existing literature on the efficacy of HBOT in managing radiation-induced toxicity and enhancing radiotherapy.
  • To evaluate the mechanisms by which HBOT influences tissue oxygenation and treatment response.

Main Methods:

  • Bibliographic review of published studies on hyperbaric oxygen therapy and radiotherapy.
  • Analysis of evidence grading for HBOT's effects on radiation injuries and tumor control.

Main Results:

  • Grade B and C evidence indicates HBOT at >2 atmospheres absolute (ata) reduces late toxicity in head and neck, bone, prostate, and bladder.
  • HBOT appears to prevent osteoradionecrosis following dental extraction in irradiated sites.
  • HBOT at 2 ata demonstrated increased radiotherapy effectiveness for head and neck tumors and promising local control for high-grade gliomas.

Conclusions:

  • HBOT is effective in mitigating late-onset radiation toxicity across multiple anatomical sites.
  • Hyperbaric oxygen therapy shows potential as an adjunct to radiotherapy, enhancing treatment efficacy and tumor control.
  • Further research into HBOT's role in oncology is warranted.