Related Experiment Video

Updated: Nov 29, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.6K

Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and

Vignesh Chidambaram1, Nyan Lynn Tun1, Waqas Z Haque1

  • 1Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

Plos One
|November 18, 2020
PubMed

Insights

Older age, male gender, diabetes, and hypertension increase COVID-19 mortality risk. Factors like dyspnea, bilateral lung involvement, and elevated inflammatory markers indicate severe disease and higher mortality in Coronavirus disease (COVID-19) patients.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Critical Care Medicine

Background:

  • Understanding factors influencing Coronavirus disease (COVID-19) severity and mortality is crucial for patient triage.
  • A systematic review was conducted to identify demographic, clinical, laboratory, and radiological predictors.

Purpose of the Study:

  • To systematically review and identify factors associated with disease severity and mortality in COVID-19 patients.
  • To inform clinical decision-making and resource allocation for COVID-19 care.

Main Methods:

  • Systematic literature search of PubMed, Embase, and WHO databases up to May 8, 2020.
  • Inclusion of observational studies comparing clinical characteristics of non-survivors vs. survivors and severe vs. non-severe cases.
  • Independent data extraction and quality assessment by two authors.

Main Results:

  • Increasing age, male gender, dyspnea, diabetes, and hypertension were associated with higher mortality risk.
  • Severe disease was linked to congestive heart failure, hilar lymphadenopathy, bilateral lung involvement, and reticular patterns on imaging.
  • Leukocytosis, lymphopenia, elevated C-reactive protein, LDH, and D-dimer levels correlated with increased odds of severe disease and mortality.

Conclusions:

  • Identified factors can aid in clinical decision-making for COVID-19 patient management.
  • Knowledge of these predictors supports critical-care resource allocation during the pandemic.
Abstract

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.8K

Related Concept Videos

Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.8K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.1K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.6K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
2.4K
Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
195
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
5.9K