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Updated: Nov 29, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Two-dimensional materials in biomedical, biosensing and sensing applications.

Nasuha Rohaizad1, Carmen C Mayorga-Martinez, Michaela Fojtů

  • 1NTU Institute for Health Technologies, Interdisciplinary Graduate School, Nanyang Technological University, Singapore.

Chemical Society Reviews
|November 18, 2020
PubMed
Summary
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Explore diverse two-dimensional (2D) materials beyond graphene for advanced applications. This review highlights their potential in biosensing, drug delivery, and therapies, emphasizing property-performance relationships for future innovations.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemistry

Background:

  • Two-dimensional (2D) materials are revolutionizing research due to their unique properties.
  • Graphene is well-known, but a vast array of other 2D materials offer significant potential.

Purpose of the Study:

  • To provide a comprehensive overview of 2D materials beyond graphene.
  • To discuss their applications in biomedical and environmental monitoring.
  • To highlight the structure-property-performance relationships influencing their utility.

Main Methods:

  • Literature review and synthesis of existing research on various 2D materials.
  • Analysis of applications including biosensors, therapeutic agents, and chemical sensing.
  • Examination of material properties such as crystal phase, conductivity, and optical characteristics.

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Main Results:

  • Diverse 2D materials like transition metal dichalcogenides, Xenes, MXenes, and others show promise.
  • These materials are effective in biosensing, drug delivery, photothermal therapy, and chemical sensing.
  • Material properties (e.g., photoluminescence, optical absorption, conductivity) critically influence performance and toxicity.

Conclusions:

  • 2D materials possess tunable properties for advanced biomedical and environmental applications.
  • Emerging materials like germanene and silicene expand the landscape of 2D material possibilities.
  • Continued research into structure-property relationships will unlock further potential for these versatile materials.