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Updated: Nov 29, 2025

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
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Extracellular vesicles and oncogenic signaling.

Antonia Schubert1,2, Michael Boutros1

  • 1Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, Germany.

Molecular Oncology
|November 18, 2020
PubMed
Summary

Extracellular vesicles (EVs) are key in cancer signaling and therapy. This review details how EVs mediate oncogenic pathways and discusses their therapeutic potential and knowledge gaps.

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Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Extracellular vesicles (EVs) are increasingly recognized for their role in cancer.
  • Understanding EV signaling mechanisms is crucial for cancer diagnostics and therapeutics.
  • EVs mediate complex intercellular communication in the tumor microenvironment.

Purpose of the Study:

  • To review current knowledge on EV biogenesis and function in cancer.
  • To focus on EV interactions with recipient cells and oncogenic signaling pathways.
  • To discuss translatable EV functions and identify existing knowledge gaps.

Main Methods:

  • Literature review of EV research.
  • Analysis of EV roles in tumor-stroma interactions.
  • Focus on Wnt, TGF-β, PD-L1, and VEGF signaling pathways.

Main Results:

  • EVs utilize diverse mechanisms for signaling specificity and cargo transfer.
  • EVs play roles in oncogenic and cancer-associated signaling cascades.
  • Interplay between EVs and signaling pathways influences tumor progression and metastasis.

Conclusions:

  • EVs are promising diagnostic and prognostic markers for cancer therapy.
  • Further research is needed to elucidate in vivo EV signaling mechanisms.
  • Translational applications of EVs in cancer therapy require addressing current knowledge gaps.