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The Dueling Duo: IL10 and TNF Face Off in Microglial Recovery from Endotoxin Challenge
Paras Singh Minhas1, Aarooran Sivakumaran Durairaj1, Katrin I Andreasson2
1Department of Neurology, Stanford University, Stanford, CA, USA.
Abstract:
The molecular mechanisms that restore microglial quiescence after acute stimulation remain largely unexplored, unlike those that drive microglial activation. In this issue of Immunity, Shemer et al. discover that the microglial IL-10 receptor counteracts the pro-inflammatory effects of TNF to allow restoration of microglial quiescence after peripheral endotoxin challenge.
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