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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Corticosteroids and circadian rhythms in the cardiovascular system

Monica Kanki1, Morag J Young2

  • 1Cardiovascular Endocrinology Laboratory, Baker Heart & Diabetes Institute, Melbourne, VIC, Australia; Cardiovascular Endocrinology Laboratory, Hudson Institute of Medical Research, Clayton, VIC, Australia; Department of Molecular & Translational Science, Monash University, Clayton, VIC, Australia.

Current Opinion in Pharmacology
|November 18, 2020
PubMed

Insights

The mineralocorticoid receptor (MR) interacts with the heart

Area of Science:

  • Cardiovascular Biology
  • Endocrinology
  • Chronobiology

Background:

  • The mineralocorticoid receptor (MR) is crucial for cardiac function and disease.
  • Mineralocorticoid receptor antagonists (MRAs) show efficacy in heart failure but have side effects.
  • The circadian clock is a newly identified partner of the MR in the heart.

Purpose of the Study:

  • To review the role of the MR in regulating the cardiac circadian clock.
  • To explore the implications of MR-circadian clock interactions in heart disease.

Main Methods:

  • Literature review of studies on MR, GR, and circadian clock genes in the heart.
  • Analysis of reciprocal interactions between MR signaling and circadian rhythms.

Main Results:

  • The MR, similar to the glucocorticoid receptor (GR), influences circadian clock gene expression and timing.
  • Dysregulation of the MR-circadian clock axis is linked to cardiac disease progression.

Conclusions:

  • The MR is a key regulator of the cardiac circadian clock.
  • Understanding this interaction may lead to improved MR-targeted therapies for heart failure with reduced side effects.

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