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Hiding in Plain Sight: Virtually Unrecognizable Memory Phenotype CD8+ T cells

Daniel Thiele1, Nicole L La Gruta1, Angela Nguyen1

  • 1Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton VIC 3800, Australia.

International Journal of Molecular Sciences
|November 19, 2020
PubMed

Virtual memory T (TVM) cells are a recently described population of conventional CD8+ T cells that, in spite of their antigen inexperience, express markers of T cell activation. TVM cells exhibit rapid responsiveness to both antigen-specific and innate stimuli in youth but acquire intrinsic antigen-specific response defects in the elderly. In this article, we review how the identification of TVM cells necessitates a re-evaluation of accepted paradigms for conventional memory T (TMEM) cells, the potential for heterogeneity within the TVM population, and the defining characteristics of TVM cells. Further, we highlight recent literature documenting the development of TVM cells as a distinct CD8+ T cell lineage as well their biological significance in the context of disease.

Keywords:
CD8+ T cellsEomesIL-15virtual memory T cells

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