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Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
Published on: July 11, 2016
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The Genus Ochrobactrum as Major Opportunistic Pathogens
Michael P Ryan1,2, J Tony Pembroke2
1Department of Applied Sciences, Limerick Institute of Technology, Moylish, V94 EC5T Limerick, Ireland.
Microorganisms
|November 19, 2020
Summary
Ochrobactrum species, related to Brucella, are increasingly recognized as opportunistic pathogens. This review highlights 128 documented Ochrobactrum infections, suggesting they pose a greater threat than previously understood.
Area of Science:
- Microbiology
- Bacteriology
- Infectious Diseases
Background:
- Ochrobactrum are Gram-negative, non-enteric bacteria, closely related to Brucella.
- Several Ochrobactrum species have been identified since 1988 and linked to opportunistic infections.
- These bacteria are increasingly implicated in various outbreaks.
Purpose of the Study:
- To review the Ochrobactrum genus, including its species, identification methods, and pathogenicity.
- To analyze data from recent whole-genome sequencing of Ochrobactrum.
- To assess the significance of Ochrobactrum infections based on published literature.
Main Methods:
- Literature review of Ochrobactrum infections.
- Analysis of diagnostic tools for Ochrobactrum identification.
- Examination of whole-genome sequencing data for Ochrobactrum species.
- Compilation and analysis of reported Ochrobactrum pathogenicity.
Main Results:
- The review identified 128 documented instances of Ochrobactrum spp. infections in the literature.
- Ochrobactrum infections are linked to opportunistic pathogenicity.
- Whole genome sequencing data provides insights into Ochrobactrum biology.
Conclusions:
- Ochrobactrum spp. are more significant pathogens than previously recognized.
- Clinical microbiology laboratories should consider Ochrobactrum outbreaks when isolated from multiple patients.
- Further investigation into Ochrobactrum pathogenicity and diagnostics is warranted.
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