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Related Concept Videos

Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Related Experiment Video

Updated: Nov 29, 2025

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Essential Current Concepts in Stem Cell Biology.

Manuela Monti1

  • 1Biotechnology laboratories, Fondazione IRCCS Policlinico San Matteo, Pavia. M.Monti@smatteo.pv.it.

European Journal of Histochemistry : EJH
|November 19, 2020
PubMed
Summary

Stem cell biology is a complex, transdisciplinary field. It integrates diverse techniques across all life organization levels, from molecular to morphological, to advance scientific understanding.

Area of Science:

  • Stem cell biology
  • Transdisciplinary research
  • Life sciences

Background:

  • Stem cell (SC) biology is a complex, transdisciplinary field.
  • It spans all levels of life organization, from molecular to morphological.
  • SC research integrates diverse techniques, from cellular to molecular levels.

Purpose of the Study:

  • To provide a comprehensive overview of stem cell biology.
  • To highlight the interdisciplinary nature of stem cell research.
  • To discuss the integration of various techniques in the field.

Main Methods:

  • Literature review of stem cell research.
  • Synthesis of information across different scientific disciplines.
  • Analysis of techniques used in stem cell biology.

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High Efficiency Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes and Characterization by Flow Cytometry
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
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High Efficiency Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes and Characterization by Flow Cytometry
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Main Results:

  • Stem cell biology is inherently transdisciplinary.
  • A wide array of techniques are employed in SC research.
  • Research spans from molecular mechanisms to morphological outcomes.

Conclusions:

  • Stem cell biology is a dynamic and evolving field.
  • Interdisciplinary collaboration is crucial for advancements in SC research.
  • The integration of diverse methodologies drives progress in understanding stem cells.