Related Experiment Video

Updated: Nov 29, 2025

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

2.5K

Hepatitis C and beta-thalassemia major in children: experience with glecaprevir/pibrentasvir

Diannet Quintero García1, Francisco José Sebastián Cuevas1, Elena Crehuá Gaudiza1

  • 1Pediatría, Hospital Clínico Universitario de Valencia, España.

Revista Espanola De Enfermedades Digestivas
|November 19, 2020
PubMed

Insights

Hepatitis C virus (HCV) affects millions of children globally. A Pakistani child with beta-thalassemia and HCV was successfully treated with glecaprevir/pibrentasvir, highlighting effective treatment options.

Area of Science:

  • Hepatology
  • Pediatrics
  • Virology

Background:

  • Hepatitis C virus (HCV) impacts 3.26 million children worldwide.
  • Pakistan and China report the highest pediatric HCV cases.
  • Iatrogenic transmission is a key route in low-income settings, contrasting with vertical transmission in industrialized nations.

Purpose of the Study:

  • To present a case study of a pediatric patient with co-existing beta-thalassemia major and Hepatitis C.
  • To demonstrate the efficacy of glecaprevir/pibrentasvir in treating Hepatitis C in a pediatric patient.

Main Methods:

  • Case report of a 12-year-old Pakistani child.
  • Diagnosis of Hepatitis C virus infection and beta-thalassemia major.
  • Treatment with glecaprevir/pibrentasvir.

Main Results:

  • Successful treatment of Hepatitis C in the pediatric patient.
  • Demonstration of glecaprevir/pibrentasvir's effectiveness in this case.
  • Management of co-existing beta-thalassemia major.

Conclusions:

  • Glecaprevir/pibrentasvir offers a successful treatment for Hepatitis C in children.
  • Effective management strategies are crucial for pediatric patients with co-morbidities like beta-thalassemia major.
  • Addressing iatrogenic transmission is vital in low-income settings for controlling pediatric HCV.

More Related Videos

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine09:54

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

Published on: November 4, 2018

8.4K
Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.6K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
94
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
90
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.7K