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Updated: Nov 29, 2025

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
11:12

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

8.2K

The Potential Use of RNA-based Therapeutics for Breast Cancer Treatment

Yangyang Song1, Xinyu Ke1, Leilei Chen1

  • 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.

Current Medicinal Chemistry
|November 19, 2020
PubMed

Insights

RNA therapy offers a promising approach to combat breast cancer by precisely targeting cancer cells. This review explores RNA therapeutics

Area of Science:

  • Oncology and Molecular Medicine

Background:

  • Breast cancer is a leading cause of cancer-related deaths globally, presenting significant treatment challenges due to its heterogeneity.
  • Tumorigenesis, metastasis, and drug resistance are key aspects of breast cancer heterogeneity that complicate treatment strategies.

Purpose of the Study:

  • To review the classifications, mechanisms, advantages, and challenges of RNA therapy in breast cancer treatment.
  • To highlight the current applications and future directions of RNA therapeutics for breast cancer.

Main Methods:

  • This mini-review synthesizes information on RNA therapy from cell culture, animal models, and clinical trial data.
  • It examines the regulatory roles of RNA in gene expression, focusing on selectivity and reduced off-target effects.

Main Results:

  • RNA therapy demonstrates anti-proliferative and pro-apoptotic effects in various models of breast cancer.
  • RNA-based drugs offer high selectivity and a low risk of off-target effects, making them attractive therapeutic agents.

Conclusions:

  • RNA therapy is a potent strategy for breast cancer treatment, with demonstrated efficacy and safety.
  • Further research and clinical trials are essential to fully realize the potential of RNA therapeutics in combating breast cancer.
Keywords:
Breast cancerRNA interference (RNAi)RNA therapyantisense oligonucleotides (ASOs)aptamersclustered regularly interspaced short palindromic repeat/CRISPR-associated protein 9 (CRISPR/Cas9).

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