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Facile preparation of purine and pyrimidine 2-deoxy-beta-D-ribonucleosides by biotransformation on encapsulated cells
1Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Praha 6.
Nucleic Acids Symposium Series
|January 1, 1987
Abstract:
A preparative-scale synthesis of pyrimidine or purine 2'-deoxy-beta-D-ribonucleosides from a heterocyclic base and 2'-deoxyuridine proceeds by biotransformation reaction in the presence of thymine-dependent E. coli mutant cells encapsulated in alginate gel. The products are isolated by octadecyl-silica or ion-exchange chromatography.